The Belvedere Research Center is continuing its conference series on the digital transformation of art museums with its fourth event on the topic. The COVID-19 pandemic, and our resultant inability to experience proximity to people and objects, has given the matter additional “virulence” in museums. Although the topic of digitization was gaining ground before the pandemic, the measures taken against the virus created a very special experimental arrangement in which the digital presence of museums was no longer merely a possible extension of exhibition spaces but rather the only way to reach the public. While the focus of our 2021 conference explored the premise of a crisis-induced return to the museum’s own collections, this time it shifts to questions beyond binary concepts, such as media specificity, hybridity, and mixed reality. In five thematic blocks, the lectures of the online conference by international experts deal with how the digital and the analog can be productively, conceptually, and aesthetically interwoven in a museum setting.